The research environment at LMU-CVM provides a unique opportunity for developing exciting research experiences in a wide range of projects. A random sampling of our focus areas is offered below:
1. Cancer Research: Projects in cancer research include feline fibrosarcoma trial evaluating a Canary Pox vector that contains the gene for feline IL-2, a canine lymphoma trial evaluating a plasmid vector encoding the gene for canine CD20, and an equine melanoma trial evaluating a plasmid vector encoding the gene for human tyrosinase.
In addition, research is also focused on developing improved diagnostics for cancers of animals. This includes developing enhanced prognostication techniques and to direct effective treatments.
2. Infectious diseases: Leptospirosis research at LMU-CVM is aimed at understanding pathogenesis of the disease, its ecology, and the development of improved diagnostic tests. Current projects on Lyme disease are geared towards understanding the molecular interactions between the etiological agent, Borrelia burgdorferi and its tick vector, Ixodes scapularis.
The members of our parasitology research team are interested in understanding various aspects of human and animal parasitic diseases, including toxoplasmosis and dirofilariasis.
3. Lipidomics: Our metabolomics facility utilizes a high-resolution mass spectrometry platform to assess lipidomics in health and disease. Some of the ongoing projects include, an exploratory lipidomics evaluation of equine lung surfactant, equine metabolic syndrome, Rhodococcus equi infection in foals, the effects of DHA supplementation on equine sperm, an exploratory lipidomics evaluation of equine plasma from control and dewormed horses, and of NSAID toxicity in cats.
4. One Health: The Center for Animal Health in Appalachia (CAHA) conducts research projects aimed at improving animal and public health throughout the Appalachian region. Among many other activities, CAHA is involved in public education and advocacy on animal health and public health issues affecting the Appalachian region. CAHA published its first Annual State of Animal Health in Appalachia report in Fall 2015.
5. Recurrent Airway Obstruction: Researchers at LMU-CVM are interested in understanding the role of lung surfactants in RAO. Recent studies compared the lung surfactant alterations in diseased versus healthy horses and in neonatal foals versus adult horses. Current projects are aimed at exploring the composition of equine broncho-alveolar lavage fluid with an aim to identify disease markers that could indicate a horse’s susceptibility to respiratory disease.
6. Simulation: The use of simulation in veterinary education enables students to learn and practice clinical skills and procedures in a safe, standardized environment without compromising animal welfare. Clinical skills research at LMU-CVM seeks to develop and validate new clinical skills training models, assess the use of skills training models in the veterinary curriculum and investigate factors affecting student performance in the clinical skills laboratory including features of models that enhance student learning.
7. Theriogenology: Ongoing projects examine the effects of a commercial blood product extender on canine semen morphology and motility. In addition, different strategies to extend semen longevity are being investigated.