MEDICAL TECHNOLOGY
PROGRAM
MEDT
452: Clinical Chemistry II
3 Credit Hours Spring Semester
INSTRUCTOR: Dr. Bill Engle, Th.D., MT(ASCP)
Office: 208 Farr-Chinnock Hall
Telephone: LMU: 1-800-325-0900, ext. 6471
Home:
(606) 337-5201
E-mail: bengle@lmunet.edu
Office
Hours: Tuesday: 8:00am
to 11:00 am
Thursday:
Instructor
will be available for student conference during
office hours
and also by appointment.
PREREQUISITE: MEDT 451: Clinical
Chemistry I
COREQUISITE: MEDT 492: Advanced
Clinical Practice II
(Chemistry Section)
COURSE DESCRIPTION: This course consists of pathophysiology,
principles of biochemical tests,
and methods of analysis in Clinical Chemistry.
Correlation of laboratory results with the diagnosis of disease is
emphasized.
TEXTBOOKS: Kaplan, Lawrence A. and Pesce, Amadeo J. (2003).
Clinical
Chemistry: Theory, Analysis, and Correlation, 4th Edition.
Kee, Joyce Lefever. (2002).
Laboratory and Diagnostic Tests,
6th
Edition. New Jersey: Prentice Hall.
METHODS OF INSTRUCTION: Lecture and
Discussion
Assigned Reading
Case Studies
Clinical Correlation
MEDT 452
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COURSE OBJECTIVES: Upon completion of this course, the student
will be responsible for attaining the following objectives:
1. Be
able to interpret chemistry results in case studies to identify diseases or
abnormal conditions, as discussed in
class.
2.
Describe hormone regulation of bones, identify change of analytes in
disease, and
discuss methods of analysis.
3.
Explain the physiology of pancreatic function, recognize change of
analytes in disease,
and identify methods of analysis.
4. Recall
the physiology of gastrointestinal function, identify change of analytes in
disease, and recognize methods of
analysis.
5.
Describe the purpose of each gastrointestinal function test, as studied
in class, and be
able to interpret results.
6. Identify
the enzymes associated with muscle, recognize change of enzymes and
isoenzymes in disease, and discuss
methods of analysis.
7.
Distinguish among the types of diabetes, and summarize methods of
glucose analysis.
8.
Classify lipoprotein disorders as to type, and describe methods of
analysis.
9.
Assess iron, porphyrin, and hemoglobin formationthrough laboratory
tests, as
discussed in class, and correlate with methods
of analysis.
10. Distinguish between water-soluble and
water-insoluble vitamins.
11. Identify analytes associated with pregnancy,
and discuss methods of analysis.
12.
Associate each hormone, as discussed in
class, with its function; describe
methods of
measuring
hormones in special chemistry.
13. Define tumor marker and relate each tumor
marker to its origin, as discussed in
the textbook.
14. Describe the process of therapeutic drug
monitoring, and discuss techniques that are
commonly used in toxicology.
15. Demonstrate mature behavior by attending
class on time and reviewing notes
from the previous lecture prior to each
class.
MEDT
452
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3
EVALUATION METHOD:
There
will be four written exams and a comprehensive final exam in this class. Quizzes and homework assignments will also be
given, and these will count toward the overall grade as indicated below.
Exam
#1: 15% of final grade
Exam
#2: 15% of final grade
Exam
#3: 15% of final grade
Exam
#4: 15% of final grade
Quizzes/Homework: 15% of final grade
Final Exam: 25%
of final grade
Grading scale is: A = 90-100%
B+
= 87- 89 % Medical
Technology students are
B
= 83- 86 % required
to maintain an average of
B- = 80-
82 % 80% or above in order to
pass this
C+
= 77- 79 % course.
C
= 73- 76 %
C- = 70-
72 %
D
= 60- 69 %
F
= below 60%
Class attendance is expected. Exams and quizzes must be taken on assigned
day unless prior arrangements are made with instructor. If a student misses an exam and/or a quiz, a
make-up exam or quiz will be offered, but the format will be at the
instructor’s discretion.
Disability
Statement: Any student with a disability requiring special
accommodation(s) should make an appointment with the Vice-President for Student
Affairs (LMU extension 6393) to discuss specific needs.
Academic
Integrity: It is the aim of the
faculty of
UNITS OF
INSTRUCTION:
UNIT I: Acid-Base Balance
Renal
Function
Liver
Function
Bone Disease
Pancreatic Function
Gastrointestinal
Function
MEDT 452
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UNITS OF INSTRUCTION (continued):
UNIT II: Cardiac Function
Diabetes
Mellitus
Coronary
Artery Disease
Iron and
Bilirubin Metabolism
Trace
Elements
Vitamins.
UNIT III: Pregnancy and Fetal Development
Endocrinology
Thyroid
Function
Adrenal
Hormones.
UNIT IV: Clinical Enzymology
Isoenzymes
Toxicology
TDM
Substance
Abuse.
Tentative Lecture Schedule
Date Textbook
Assignment Topics
Tues.
Review
of Syllabus
Review of Acid-Base Balance & Control
Tues.
Tues.
Thurs. 1/29/04 Chapter 30 Gastrointestinal Function and Disease
Tues.
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452
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Tentative Lecture Schedule (continued):
Date Textbook
Assignment Topics
Thurs.
Tues..
Tues.
Tues. 2/24/04 Chapter
39 Vitamins
Tues. 3/2/04 Chapter
40 Pregnancy
and Fetal Development
Tues.
Tues.
Spring Break (no classes) March 22 thru
Tues.
Thurs. 4/01/04 Chapter 55 Isoenzymes and Isoforms
Tues..
Tues. 4/13/04 Chapter
52 Addiction
Abuse
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452
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Tentative Lecture Schedule (continued):
Date Textbook
Assignment Topics
Tues. 4/20/04 Chapter
49 Neoplasia
Tues. 4/27/04 FINAL EXAM
DATE OF REVISION: January, 2004