BIOLOGY 210

Genetics

I. BIOL 210, Genetics, 4 semester hours: 3 lec. & 1 lab

II. Fall 2001, Dr. John E. Copeland, Office hours posted on office door, Room 203 FC Hall, 615‑869‑6225 or email j jcopeland@inetlmu.lmunet.edu

III. Course Prerequisites: BIOL 111 & 112

Course corequisite: BIOL 210 lab

IV. Course Description: Survey of Mendelian genetics,

exceptions to Mendelian genetics, Biochemical genetics,

and basic population genetics

Course Goals:

1. To instruct students as to Mendelian genetics

2. To instruct students as to the exceptions to Mendelian

genetics

3. To instruct students as to the relationship between

meiosis and Mendel's postulates

4. To instruct students as to DNA replication transcription

translation and genetic engineering

5. To instruct students as to quantitative genetics and

population genetics

V. Relationship of this course content to area knowledge and

skills:

Laboratory safety procedures will be explained.

The historical development of genetics as a science is

discussed starting with Plato and Socrates continuing

to modern day events. The contributions of Plato,

Socrates, Lamarck, Darwin, Mendel, Bateson, Beadle,

Tatum, Chargaf, Calvin, Watson & Crick, et al.

The cell theory and cell replication as well as those

cell organelles having special significance to genetics.

The role of genetics in extinctions and attempts to save

endangered species is discussed.

The ethical use of genetic engineering to solve human and

environmental problems are discussed. The impact

of such technology on the quality of life is discussed.

Darwin's theory of natural selection and the forces which drive evolution by causing changes in gene frequencies are discussed.

Mendelian genetics and exceptions to Mendelian genetics are covered.

Quantitative and population genetics are covered.

The relationship of genetics to other fields of biology and science are covered.

VI. Text: Genetics 4th ed. by Daniel L. Hartl

The Double Helix by James D. Watson

VII. Course Objectives:

Knowledge areas and skills to be mastered by students:

1. Mendelian Genetics

2. Exceptions to Mendelian Genetics

3. Mitosis and meiosis

4. Chemical structure of DNA and RNA

5. DNA replication, transcription, translation

6. Quantitative genetics

7. Basic population genetics

8. Techniques of genetic engineering

VIII. Units of Instruction:

Mendelian Genetics

Mitosis and Meiosis

Exceptions to Mendelian Genetics

Autosomal and sex‑linked inheritance

Crossing Over and Mapping

Structure od DNA and RNA

DNA replication

Transcription

Translation

Quantitative Inheritance

Extrachromosomal Inheritance

Population Genetics

Genetic Engineering

IX. Required Readings: Course texts and the following:

Mendel, G., 1866. Experiments in plant hybridization. Proceedings of the Brunn Natural History Society

Watson, J. D., and Crick, F. C., 1953. Genetic

implications of the structure of deoxyribose

nucleic acid. Nature 171:964

X. Suggested Readings: None

XI. Methods of Instruction and Learning: Instruction will occur in two ways, lectures and laboratory exercises.

Students will be responsible for keeping an up‑to‑date

notebook of topics covered in lecture and laboratory.

During laboratory periods, students will be directed

through exercises and problems. These exercises

will expand upon topics discussed in lecture and will

include the use of statistics to interpret results.

Learning will be accomplished through listening to

lectures, studying notes, reading of text and

assigned readings, and through experimentation

and problem solving.

XII. Course requirements/Evaluation Methods: Students are expected to attend every class meeting. A student may

miss three classes. Each absence after the third will result in the student's grade being lowered an entire

letter grade. To successfully compete this course students are expected to complete three or four lecture exams

while maintaining an average of seventy percent. There will be no "pop quizzes" or unannounced exams. Students will be given at least one week advanced notice of exams. The grading scale is A = 100‑90%, B = 89‑80%, C = 79‑70%, D = 69‑60%, F = 59‑0%. Students who miss an exam have one week from the date of the exam in which they can make it up. After this time a grade of zero will be recorded.

XIII. Laboratory Experiences:

Cell structure, function, mitosis, meiosis

Mendelian genetic problems

Exceptions to Mendelian genetics

Use of probabilities in genetic analysis

Chi‑square analysis

Linkage, crossing over, chromosome mapping

Multiple alleles

Gene interactions

Population genetics, Hardy‑Weinberg law

Pedigree analysis

Electrophoresis: DNA Fingerprinting, Genetic Distance

XIV. Date of Revision: 8/20/01